![]() ![]() These experts measured various health parameters in mice and found that at age 2 (60 in human years), animals supplemented with taurine for one year were healthier in almost every way than their untreated counterparts. To learn how taurine impacted health, Yadav brought in other aging researchers who investigated the effect of taurine supplementation on the health and lifespan in several species. For the mice, that meant three to four extra months, equivalent to about seven or eight human years. At the end of the experiment, Yadav and his team found that taurine increased average lifespan by 12% in female mice and 10% in males. Every day, the researcher fed half of them a bolus of taurine or a control solution. "That's when we started to ask if taurine deficiency is a driver of the aging process, and we set up a large experiment with mice," Yadav says.The researchers started with close to 250 14-month-old female and male mice (about 45 years old in people terms). In people, taurine levels in 60-year-old individuals were only about one-third of those found in 5-year-olds. "We realized that if taurine is regulating all these processes that decline with age, maybe taurine levels in the bloodstream affect overall health and lifespan," Yadav said.įirst, Yadav's team looked at levels of taurine in the bloodstream of mice, monkeys, and people and found that the taurine abundance decreases substantially with age. Around the same time, other researchers were finding that taurine levels correlated with immune function, obesity, and nervous system functions. Taurine first came into Yadav's view during his previous research into osteoporosis that uncovered taurine's role in building bone. If a molecule is a driver of aging, then restoring its youthful levels would delay aging and increase healthspan, the years we spend in good health. Less certain is whether these molecules actively direct the aging process or are just passengers going along for the ride. Many studies have found that various molecules carried through the bloodstream are associated with aging. Over the past two decades, efforts to identify interventions that improve health in old age have intensified as people are living longer and scientists have learned that the aging process can be manipulated. ![]() "This study suggests that taurine could be an elixir of life within us that helps us live longer and healthier lives." "For the last 25 years, scientists have been trying to find factors that not only let us live longer, but also increase healthspan, the time we remain healthy in our old age," says the study's leader, Vijay Yadav, PhD, assistant professor of genetics & development at Columbia University Vagelos College of Physicians and Surgeons.ĪLSO READ: How to take care of fitness in your 40s, what are the health risks involved ![]() The findings of the study were published June 8 in Science. Further studies are required to determine the benefits of replenishing taurine pools as well as the need to include taurine routinely in parenteral nutrition regimens.Stay tuned with breaking news on HT Channel on Facebook. patients requiring long-term parenteral nutrition (including premature and newborn infants) those with chronic hepatic, heart or renal failure. Specific groups of individuals are at risk for taurine deficiency and may benefit from supplementation, e.g. Taurine is an essential amino acid for preterm neonates and is assured by breast milk. ![]() Taurine has a unique chemical structure that implies important physiological functions: bile acid conjugation and cholestasis prevention, antiarrhythmic/inotropic/chronotropic effects, central nervous system neuromodulation, retinal development and function, endocrine/metabolic effects and antioxidant/antiinflammatory properties. In healthy individuals the diet is the usual source of taurine although in the presence of vitamin B6 it is also synthesised from methionine and cysteine. This comprehensive overview explores areas, from its characterisation to its potential clinical benefit as a conditionally essential amino acid and a pharmaconutrient. Taurine, a sulphur containing amino acid, is the most abundant intracellular amino acid in humans, and is implicated in numerous biological and physiological functions. ![]()
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